Analytical Scientist – SEC Chromatography
The Analytical Scientist – SEC Chromatography will support analytical development and routine testing for biological therapeutics in a regulated laboratory environment. This role requires hands-on experience performing Size Exclusion Chromatography (SEC) using HPLC/UPLC systems.
Key responsibilities include independently performing SEC-based HPLC/UPLC testing in support of biological product release and characterization. The scientist will also execute additional analytical techniques as required, including CEX, RP-HPLC, P20/P80, CE, icIEF (Maurice), iCE, and CE-SDS (Maurice and PA800). Responsibilities encompass method execution, data review, and documentation using established test methods, protocols, and reporting standards. The role demands applying sound scientific judgment for method execution, data interpretation, and problem-solving for studies of moderate scope and complexity. Demonstrating HPLC/UPLC troubleshooting skills, particularly related to SEC performance, system suitability, and chromatographic behavior, is essential. All activities must be conducted in compliance with cGMP/GLP, safety, and regulatory requirements. Additionally, the scientist will support non-laboratory tasks such as documentation, data review, or protocol support as assigned.
Required qualifications include a Bachelor’s degree in Analytical Chemistry, Biochemistry, Cell & Molecular Biology, Pharmaceutical Sciences, or a related discipline with 2+ years of hands-on HPLC/UPLC experience, including direct experience performing SEC chromatography, or a Master’s degree in a related scientific field with 6+ months of directly relevant hands-on HPLC/UPLC experience, including SEC acquired through internships, co-ops, or industry roles. A demonstrated understanding of SEC chromatography principles, protein separation techniques, and chromatographic theory is necessary. Working knowledge of HPLC/UPLC and CE instrumentation, data integrity practices, and industry standards is required. The candidate must have the ability to manage multiple tasks, learn new techniques, maintain accurate records, and follow SOPs. Authorization to work in the United States indefinitely without restriction or sponsorship is mandatory.
Preferred qualifications include experience with biologics characterization, protein aggregation analysis, or therapeutic protein release testing. Prior experience working in a regulated (cGMP and/or GLP) laboratory environment is advantageous.
The position is full-time, first shift, Monday-Friday with overtime as needed. Candidates living within a commutable distance of Lexington, MA are encouraged to apply. Compensation ranges from $31.00 to $34.00 per hour based on education and experience. Excellent full-time benefits include comprehensive medical coverage, dental, and vision options, life and disability insurance, 401(k) with company match, and paid vacation and holidays.